How to Save a Life: The World’s First Heart Transplant

Dr. Christiaan Barnard greeting Louis Washanky after surgery| Courtesy of Flickr: Creative Commons

“Life to me is so very valuable that I doubt if a minimum time limit can be set on it.” –Christiaan Barnaard1

What does the beat of your heart sound like? It sounds pretty much like any other heart, right? What if this heart was not your own? What if this heart had belonged to someone else before you? The sound isn’t so ordinary anymore now is it?

A photograph of heart donor Denise Darvall | Courtesy of new24.com

On December 2, 1967, twenty-five year old Denise Darvall and her mother were crossing the street trying to get to a well-known bakery. The mother and daughter were making their way to the car with the pastry in hand when the unthinkable happened. A drunk driver, paying no attention to his surroundings and running a red light, sped through the crosswalk, taking out the two ladies in his path. Denise’s mother was killed on impact, and upon arrival at the hospital, Denise would be declared brain dead.2 Her father made the decision on her behalf to save the life of another individual and give someone else another chance to live. Denise and her mother fell victim to this reckless act and ultimately lost their lives. Denise had now past away, but her death would not be in vain. Though she may not have known, Denise would become a part of medical science history.

Dr. Christiaan Barnard was born in the year 1922, and received his education at the University of Cape Town in 1946. After receiving the training necessary to become a surgeon, Christiaan helped develop an open-heart surgery program at the hospital where he worked, Grute Schuur Hospital.3 He had also had help from Stanford University to perfect his surgical techniques.4 Christiaan Barnard had numerous accomplishments under his belt already, but there was still some work that had to be done. Dr. Barnard wanted to change the world and do the unthinkable. With patients Louis Washanky and Denise Darvall, he’d be able to do just that.

Image of Dr. Christiaan Barnard | Courtesy of Wikimedia Commons

Fifty-three year old Louis Washanky was a grocer in the city of Cape Town, who had been afflicted with serious heart problems. He was quite the odd choice to be the first patient for this procedure, considering he had a history of smoking and he was also diabetic.5 Additionally, he had a massive growth on his leg that would require draining and would also be another location where infection would take place. Louis was far from being the ideal choice for a first heart transplant recipient, but nonetheless, Dr. Barnard saw something in Louis and knew that he was to be the one who would receive the new heart and get a second chance at life. Denise had been declared brain dead, but she had also been deemed an ideal donor for the impending surgery for Louis. Therefore, since she was seen as selected donor, her organs could not be allowed to become deoxygenated. So her body temperature was regulated and she was kept on a ventilator so that oxygen would still be provided to her organs to keep them functioning. Denise had the blood type O and Louis had the blood type A. This meant that Denise was viewed as a “universal” blood donor and therefore Louis could receive her blood.6 However, just because the blood types were compatible did not mean that their white blood cell types were compatible. Due to the time sensitive procedure, there was no time to determine whether Louis’s body would reject the new organ. The doctors could only move forward with the procedure and hope for the best. Louis was in the room right next to Denise’s, and once the okay was given, the historic surgery was ready to begin.

Shortly after two in the morning on December 3, 1967, the surgery was ready to take place. Denise’s body had been properly prepped for the procedure and Louis had been anesthetized. Denise’s heart had been clamped and was ready for removal and Louis’s heart had been clamped so that all the blood in his body was being directed everywhere except to his now failing heart. Once Denise’s heart was removed, it was directly put on ice and was being pumped with blood so as to keep the organ alive, whereas Louis’s heart was to never beat again. The surgeons carefully moved the donor heart into its new home and stitched the organ in like a puzzle piece. They carefully attached the aorta, the pulmonary artery, and each and every vein. The delicate procedure took an estimated four hours to complete. The moment of truth would come when it was time for the heart to beat for the first time. All hands were off the body and Dr. Barnard would shock Louis’s chest to see if the risky surgery was too good to be true. Dr. Barnard shocked Louis’s chest, and sure enough…lub-DUB, the heart began beating on its now.7

Entrance to Groote Schuur Hospital | Courtesy of Wikimedia Commons

Louis had survived the surgery and he now had a properly functioning heart, but he wasn’t out of the woods yet. He had won half the battle, but their still were no guarantees as far as Louis’s outcome would go. Now the hurdle that had to be crossed was to see if Louis would continue to survive and see if his body would handle the sudden, drastic change of a new organ. Upon Louis’s first time waking up, he appeared to be doing fine and feeling good. He was smiling and was very grateful for the second chance at life that he had been given. Dr. Barnard was overjoyed to see his first patient doing so well, but he knew that there was still a long way to go. In the coming days, Louis had seemed to be making progress and continuing to heal more each day. About two weeks after the surgery, however, Louis had taken a turn for the worse. His caretakers were uncertain as to what caused the sudden decline in health. They deemed the issue to be attributed to their worst fear: organ rejection. The caretakers decided to increase the treatment for organ rejection, which ultimately would cause Louis to become more immuno-compromised. This means that his immune system would be lowered to the point where his body could no longer fight off infection or defend itself from any potential invaders of his body. While the intentions of this action were for the benefit of Louis, the step taken to help him actually ended up being detrimental to his health. The increase of medication actually worsened his condition rather than help it. Due to his compromised immune system, Louis continued to deteriorate and he ended up contracting pneumonia, from which he unfortunately could not recover. A little over two weeks after receiving his new heart, Louis Washanky passed away due to the complications following his surgery, combined with the deadly pneumonia.8

Though Louis unfortunately passed away, his operation was still considered a success. The procedure was something that had never been done before and Dr. Barnard’s patient lived for over two weeks with the new heart. The operation would set the stage for future heart transplants to take place with even more of a success rate. From Louis’s surgery and post-op conditions, healthcare providers could learn from the operation both what went right and what went wrong. That way they could provide the best outcome possible for their patients. Dr. Barnard took a chance with this new procedure, but he opened the doors for future surgeons and patients alike to have this second chance like Louis Washanky had been given. Dr. Barnard took a chance on the procedure, and by doing so, he also helped other surgeons have the bravery to take a chance on new, life-saving surgeries as well. Of course, Denise Darvall cannot be forgotten in all of this. Though what happened to her was tragic, she helped to give Louis Washanky another two and a half weeks of life that he may not have had without her help. Her contribution can never be forgotten since the breakthrough surgery would not have been possible without her. Denise quite literally gave the most loving gift of life to Louis Washanky straight from the heart. Although bittersweet, due to the story of these three individuals and all others involved, the history of medicine was changed, and medicine today has advanced due to the sacrifices and chances taken by these brave people.

  1. Christiaan Barnard, Heart Attack: You Don’t Have to Die (New York: Delacorte Press, 1971), 5.
  2. James Brent-Styan, “PART 2: First Heart Transplant-‘Denise never saw the motor vehicle coming,’” news24. Accessed November 8, 2018. https://www.news24.com/Books/part-2-first-heart-transplant-denise-never-saw-the-motor-vehicle-coming-20171203.
  3. John Brink and Johannis Hassoulas, “The first human heart transplant and further advances in cardiac transplantation at Groote Schuur Hospital and the University of Cape Town,” Cardiovascular Journal of Africa Vol. 20(1) (2009): 31-35.
  4. “A Brief History of Heart Transplantation,” Columbia Doctors, accessed September 9, 2018. http://columbiasurgery.org/heart-transplant/brief-history-heart-transplantation.
  5. John Brink and Johannis Hassoulas, “The first human heart transplant and further advances in cardiac transplantation at Groote Schuur Hospital and the University of Cape Town,” Cardiovascular Journal of Africa Vol. 20(1) (2009): 31-35.
  6. Lily Rothman, “50 Years Ago This Week: Inside the First Heart Transplant,” Time, December 11, 2017. Accessed September 9, 2018. http://time.com/5050803/1967-heart-transplant/.
  7. Lily Rothman, “50 Years Ago This Week: Inside the First Heart Transplant,” Time, December 11, 2017. Accessed September 9, 2018. http://time.com/5050803/1967-heart-transplant/.
  8. John Brink and Johannis Hassoulas, “The first human heart transplant and further advances in cardiac transplantation at Groote Schuur Hospital and the University of Cape Town,” Cardiovascular Journal of Africa Vol. 20(1) (2009): 31-35.
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15 Comments

  • It is incredible how much medicine has advanced since 1967, to think a heart transplant/open heart surgery is sort-of an every-day procedure now. I would critique the author for not providing enough background information as to the research and education specific to the heart transplant procedure, as well as what failed in the aftermath of the first one, however, the article is about an interesting topic I did not know much about. Overall, the author could have use some more editing for grammar and flow, but I certainly learned some new information about the medical world.

  • This was a really well done article. It was incredibly interesting reading about the first heart transplant ever done. While it was ultimately unsuccessful in that Louis only lived two weeks after the transplant, what was learned from it has gone to save so many more lives today through the use of heart transplants. Denise and Louis will forever be the beginning of all the lives saved.

  • Never before had I even pondered on the first transplants. I’ve always just sorta known that it had once occurred and not offered to give any thought to the historical side of it. It’s so sad that our only way of learning in the medical transplant field is trial and error. However, it causes so much more good than bad in the long run.

  • This article is very inspirational to read especially since I had no idea who was the first person to successful do a heart transplant. It’s amazing to see how far we have come since the first heart transplant since if it wasn’t for that successful case we wouldn’t be as advance as we are today. With this case doctors were able to dissect information on what they did wrong and think of different way\s to correct it.

  • I have a ton of respect for people who are willing to donate their organs so that someone else may be able to find some use with it and live a long healthy life. I honestly thought about becoming an organ donor, but I was fearful that I may be killed so someone could have my organ sooner than expected.

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