The Origin of Gluten-Free Diet: the Discovery of Willem Dicke

Oats, barley, and some products | Courtesy of Wikimedia Commons

Today there are a variety of diets in the world that help people’s bodies be healthier, more powerful, or more attractive. Not only sports players or fashion models, but also ordinary people follow those diets for their own purposes. Among those numerous diet methods, the gluten-free diet is one of the most popular for achieving overall good health. However, very few people know who pioneered gluten-free diets or how he did it.

It was almost a hundred years ago. Many people in a variety of countries were suffering from celiac disease, which is caused by gluten in one’s diet. However, the cause of the disease had not discovered yet, at that time. Therefore, patients with the disease had no choice but to follow the latest trend: dietary cures such as a banana diet or an oyster diet.1 Although those diets did not suggest that patients eliminate gluten from their meals, the diets were successful, because both bananas and oysters don’t have gluten, and they do have rich nutrients that is good for overall health. Bananas are still considered to be excellent fruits because they contain a lot of nutrients. And oysters do too.

First, oysters are high in zinc. Zinc plays an important role in various functions of the human body, and not having zinc can cause problems. For example, zinc is important for the immune system. It affects many kinds of cells, such as natural killer cells, which eliminate cancer cells and viral-infected cells. Zinc helps the cells to develop, which means that it contributes toward preventing people from getting sick. When the amount of zinc in the body is not enough, it can even cause death of cells.2 In addition, lack of zinc can cause growth retardation. In 1958, German professor Lothar Rink visited Shiraz, Iran and observed people who had dwarfism. The patients also had other symptoms, such as rough and dry skin, mental lethargy, and anemia. Rink and other researchers found their deficiency of iron. However, lacking iron could not explain their growth retardation. Then, they concluded that it could be because of a zinc deficiency. This was because the patients mainly ate breads made from whole wheat flour, which contained phytate, the element that prevents zinc from being absorbed.3 It is not only Iranians but also people all around the world who need to take more zinc. Oysters are one of the richest foods in this essential element, containing more than 10 mg of zinc per 100 g compared to salmon, chicken, or shrimp, which contain only 1-2 mg of zinc.4

Flat oysters from Cancale | Courtesy of Wikimedia Commons

Second, oysters can be a great source of protein. In China, they have been so valued as a protein source that sports beverages are made from them. One of the reasons is because the protein in oysters is easily absorbed in the human body. Most sports beverages sold in the current market are electrolytic. However, those beverages are difficult for the human body to absorb.5 Another benefit from oysters is that they have other components that are helpful for those who engage in sports. For example, oysters contain sugar and taurine. Sugar, like protein, is used in the body to provide energy quickly and effectively; taurine is good for relieving fatigue immediately after sports activity. Other effective components include bioactive peptide, glycogen, and saline ions.6 These components are necessary for athletes, which means that perfect sports beverages can be made from oysters. Also, at the time when oyster diets were trending, they were also providing an important energy source.

Although banana diets and oyster diets were thought to be the solutions for celiac disease, they were not reliable ways to prevent symptoms. Then, Willem Dicke, a Dutch pediatrician, started research in earnest. It took a lot of time and effort. After making examinations again and again, however, he found a clue, finally. Dicke found that many of the patients who eliminated wheat products from their diets felt better. He conducted further studies to make sure that wheat had something to do with celiac disease. In the end, he concluded that the cause of this disease is the existence of gluten.7 Since people did not have any knowledge of gluten at that time, it became a remarkable discovery. Even now, many people don’t know exactly what gluten is and how it affects celiac disease and people’s overall health.

Common wheat | Courtesy of Wikimedia Commons

Gluten is a protein in various foods. It helps dough to hold its shape or expand. It is contained in many of the foods we eat daily, such as breads, pasta, cereal, cakes, and cookies. This is because the primary source of gluten is wheat. Other sources of gluten include rye, barley, and European spelt.8 Although about 80 percent of wheat gluten is used in the baking industry in America, there are a lot of other gluten-containing foods, such as french fries or soups. Most cereals contain gluten; however, oats are still under investigation. A lot of researchers have conducted experiments with oats, but they have not yet been able to get definite answers.   Further studies are needed to see whether oats are a gluten-containing cereal or not.9

Gluten is basically made up of two different kinds of protein components. One is gliadin and the other is glutenin, and gliadin is known to be harmful if it is not broken down in the body.10 The patients of celiac disease are not able to break down gliadin in their organs because of a reaction in the immune system. First, when taking gluten, bodies build up the immune system, which is mediated by an antibody called lgA. LgA attacks gastric mucosa and transglutaminase, the enzyme that dissolves gliadin. Then gliadin remains unbroken and causes various symptoms, such as skin rash, stomach pain, oral ulcers, and so on.11 The tolerable amount of gluten depends on each patient.12 Some study patients show comparatively slight symptoms, but others react more seriously, some so severe that it becomes a matter of life or death. Paul J. Ciclitira, a professor of gastroenterology, and other authors say in their book that “The importance of following a gluten-free diet by patients with celiac disease is protection against the increased risk of developing gastrointestinal malignancy, other autoimmune disorders, including diabetes mellitus and osteoporosis.”13 The recent survey by the National Board of Health, the National Institute of Diabetes and Digestive and Kidney Diseases reported that a third of adults in America feel negative effects after taking gluten, and 1 in 141 people there have celiac disease.14

Biopsy of small vowel showing coeliac disease | Courtesy of Wikimedia Commons

After Dicke discovered the cause of celiac disease, he kept studying and then announced his findings. According to David Yan and Peter Holt in their article, Dicke made five conclusions: First, when patients are on a gluten-free diet, symptoms such as vomiting and anorexia disappear and the development of young patients’ bodies is encouraged. Second, patients have diarrhea when they eat wheat or rye foods. Third, patients have diarrhea when wheat flour is used in foods instead of rice or corn flour or potatoes. Fourth, when patients have wheat, the amount of fat in the feces increases. Fifth, wheat can cause harm but wheat starch does not.15 After Dicke announced his conclusions, many researchers began to study gluten for an improvement of medical knowledge. Therefore, his discovery of the relationship between gluten and celiac disease contributed to the knowledge that we have about it today. If he had not discovered them, people might have not known about gluten-free diets, such an effective method for making their physical conditions better.

  1. David Yan et. al., “Willem Dicke. Brilliant Clinical Observer and Translational Investigator. Discoverer of the Toxic Cause of Celiac Disease,” CTS: Clinical & Translational Science 2, no. 6 (2009): 446.
  2.  Lothar Rink, Zinc in Human Health (Washington, D.C.:IOS Press, 2011), 18.
  3.  Lothar Rink, Zinc in Human Health (Washington, D.C.:IOS Press, 2011), 8-9.
  4.  Lothar Rink, Zinc in Human Health (Washington, D.C.:IOS Press, 2011), 30.
  5. Shi Hui, “The Development of Oyster Sports Beverage and Its Antifatigue Activity on Athletes After Training,” Carpathian Journal of Food Science & Technology 8, no. 1(2016): 48.
  6. Shi Hui, “The Development of Oyster Sports Beverage and Its Antifatigue Activity on Athletes After Training,” Carpathian Journal of Food Science & Technology 8, no. 1(2016): 50.
  7. David Yan et. al., “Willem Dicke. Brilliant Clinical Observer and Translational Investigator. Discoverer of the Toxic Cause of Celiac Disease,” CTS: Clinical & Translational Science 2, no. 6 (2009):446.
  8. Salem Press Encyclopedia of Health, 2015, s.v. “Gluten,” by Joseph, Dewey, PhD.
  9.  United States International Trade Commission, Wheat Gluten (United States: U.S. International Trade Commission, 1998), II-5.
  10.  Salem Press Encyclopedia of Health, 2015, s.v. “Gluten,” by Joseph, Dewey, PhD.
  11.  Magill’s Medical Guide (Online Edition), 2013, s.v. “Gluten Intolerance,” by Nicole M Hoey, Pharm.D Van.
  12.  Paul J Ciclitira, et. al., “Gluten-Free Diet–What Is Toxic?,” Best Practice & Research. Clinical Gastroenterology 19, no. 3 (2005): 364.
  13.  Paul JCiclitira, et. al., “Gluten-Free Diet–What Is Toxic?,” Best Practice & Research. Clinical Gastroenterology 19, no. 3 (2005): 360.
  14.  Salem Press Encyclopedia of Health, 2015, s.v. “Gluten,” by Joseph, Dewey, PhD.
  15.  David Yan et. al., “Willem Dicke. Brilliant Clinical Observer and Translational Investigator. Discoverer of the Toxic Cause of Celiac Disease,” CTS: Clinical & Translational Science 2, no. 6 (2009): 447.
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  • Before reading this article I had never even heard of celiac disease. Its fascinating that gluten plays such a large role in food groups and nutrition. The thing I found interesting about this article was the fact that oysters can be a great source of protein. I always thought proteins were just meats. I guess I’m just a little ignorant of the anatomy of oysters.

  • I have always been careful about how much bread I eat since gluten often conflicts with skin inflammatory issues, but i did not know gluten had much more serious effects. However, i believe to the common folk, gluten in moderation would be most ideal. Perhaps i should be stricter on my gluten consumption, although it is hard to get away from.

  • I have always heard of the gluten-free diet and know that there are individuals who are allergic to gluten, but I had no idea what gluten was. I like how this article explained the oyster and banana diets in detail, because I didn’t think that someone would willingly go out of their way to partake in these diets. Overall, I enjoyed reading this article and now hold a better understanding of the gluten-free diet.

  • I loved reading a health-based article in our webpage and was surprised by the two diets mentioned. I completely agree with diets being followed by all groups of people and not only athletes. I am curious to find how many people do not follow dietary restrictions and how our nation would average on health-related questions. I was really surprised to learn more about wheat because to my knowledge wheat was very healthy but I got the opposite feeling from this article.

  • This was a very informational article that really taught me a lot. Gluten is in almost everything so the thought of a gluten free diet surprises me. Now I know the origin of it was to help those with celiac disease which I think the diet would be the most needed or for those who are allergic to gluten.

  • Since my brother had to be on a gluten free diet for the first few years of his life I had some prior knowledge. Reading some of the other comments it is very interesting to me how many people are not aware of what they consume. I feel that this article is essential to readers and very informative. Overall the author did a great job at simplifying the topic and making it easy to understand.

  • In the past years gluten free diets have become more and more popular. I didn’t know that gluten was in so many of the foods we consume daily. While I noticed this happening I never really looked into it, this article I found out that some patients couldn’t have as much gluten as others and for some when removing gluten from their they became healthier not vomiting, getting sick.

  • Insightful article about gluten and a gluten free diet. I think that a gluten-free diet is only necessary with those who cannot have gluten in their system at all, such as those with celiac disease. However in moderation, I think gluten contributes to a healthy diet. There’s so many theories about what a good diet is these days, but then again its different for everyone. Some people are sensitive to gluten and will easily gain weight when consuming it. Others are different, but overall I think that a gluten free diet isn’t 100% necessary for those without celiac disease.

  • These diet l plans are difficult to stay aware of. Gluten is an item that is situated in nearly everything. It is additionally a thing that numerous individuals are susceptible to or need to remove their eating routine because of offering issues to their bodies. Individuals state that gluten pulverizes your wellbeing, however, I simply trust that a lot of everything crushes your wellbeing. On the off chance that you look sufficiently hard and need to discover terrible things about things you will regardless of what it is.

  • Personally, this article will not reduce the amount of gluten I eat. I like to enjoy my food, but this was an interesting article despite my choice to continue to be unhealthy. People rarely are able to explain why they choose a gluten-free diet (of course with the exception of people who actually are sensitive to gluten) so it was nice to see an in-depth look on the history of gluten-free diets

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